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| Data Details |
| Disease Name |
liver cirrhosis |
| Tissue |
liver |
| Database |
ArrayExpress |
| Data ID |
E-GEOD-49012 |
| Data Type |
expression |
| Platform |
A-GEOD-17470 |
| Species |
homo sapiens |
| Sample Number |
34 |
| PubMed ID |
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| Title |
Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis |
| Data Description |
"In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis. Hepatic CYP3A activity and miRNA microarray expression profiles were measured in cirrhotic (n=22) and normal (n=12) liver tissue. Hepatic CYP3A activity was measured via midazolam hydroxylation in human liver microsomes. Additionally, hepatic CYP3A4 protein concentration and the expression of CYP3A4 mRNA were measured. Analyses were conducted to identify miRNAs which were differentially expressed between two groups but also were significantly associated with lower hepatic CYP3A activity. Liver tissue was collected from individuals with established cirrhosis who were awaiting liver transplantation (n=22) at the time of their liver transplantation procedure in the operating room. Normal liver tissue (n=12) was obtained from patients undergoing liver resection for metastatic/benign liver lesions with no underlying chronic liver disease" |
| Keyword |
cirrhosis mirna |
| Download |
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